RECURRENT PREGNANCY LOSS DUE TO HAEMOGLOBINOPATHY (THALASSEMIA)

Thalassemia disorder is a heterogenous disorder of alpha and beta globin chain production. It results in destruction of red blood cells leading to hemolytic anemia. Pregnancy complicated by thalassemia israre to occur .It can result in pregnancy wastage when uncared for. Pregnant woman with thalassemia are prone for pre-eclampsia, intra uterine growth restriction, preterm labour and poor reproductiveoutcome. A case of pregnancy complicated by beta thalassemia is presented here. She was third gravida with full term pregnancy with severe anemia with signs of cardiac failure, severe epatosplenomegaly,severe intrauterine growth restriction resulting in fetal death. She was treated with urgent blood transfusion and delivered a fresh still born baby.Her haemoglobin was 4.2 gm%. Her haematological profile showed reduction in mean corpuscular volume and mean corpuscular haemoglobin.. Although her Hb electrophoresis showed thalassemia minor trait, there were features in favour of thalassemia intermedia.Post natal counselling was done to prevent recurrence of intrauterine death due to severe anaemia in future pregnancies.