Comparison the Anti-β2GP1 Autoantibody Level in Serum of Pregnant Women with History of Recurrent Miscarriage and Healthy Women in Gorgan

Background and objectives: Recurrent miscarriage (RM) is one of themost common reproductive disorders, generally considered to be theloss of three or more pregnancies before viability. One of the causes ofthis disorder is the immunological factors such as autoantibodiesassociated with anti-phospholipid syndrome.Material and Methods: this case-control study was conducted on 80pregnant women divided into two equal groups of healthy and RMwomen in Gorgan. The subjects were asked to fill out a questionnaireand examined by a gynecologist to distinguish their condition, healthyor RM. The blood samples were kept at -20c and assessed by bothELISA 96 and automated ELISA processor with single dose ready-tousetest to measure β2GP1 autoantibodies of IgM and IgG.Results: the results indicate that % 7.5 of RM patients are seropositivefor Anti-β2GP1 IgG, and % 5 for Anti-β2GP1 IgM , but in healthypregnants , % 7.5 are seropositive for Anti-β2GP IgG , and %7.5 forAnti-β2GP1 IgM. Family history of abortion in RM group (33.5%) issignificantly higher than healthy one (17.5%).Conclusion: based on the results, the difference between the level ofAnti-β2GP1 IgM and Anti-β2GP IgG in case and control groups is notsignificant, but the production of this autoantibody is associated withpregnancy.Key words: Autoantibody, Antiphospholipid syndrome, RecurrentMiscarriage