A Case Report of Blood Group Discrepancy because of Anti A1 with Clinical Significance and Anti C

Background and objectives: ABO phenotyping is one of theessential tests in Immunohematology. Incompatible blood grouptransfusion leads to acute hemolysis reactions and other seriouscomplications. Anti A1 is a cold Antibody with no clinicalsignificance, but if it is reacted at 37 c can be clinically significant,which will be happened rarely. At the present, we report a Case withanti A1 having clinical significance and Anti C.Material and methods: The patient was suffering from Paroxysmalnocturnal hemoglobinuria (PNH) and received repeated bloodtransfusion. The tests performed for this patient were blood grouping,Antibody screening, panel test and cross match.Result: the patient’s blood group is AB (A2B) with anti A1. Thepresence of anti C is verified by applying Panel test.Conclusion: to prepare appropriate blood, Cross mach test wasperformed on A2B blood bags without C Antigen. During laboratorytests and blood transfusion, no reaction was observed. This reportindicates that being aware of anti-antigen antibodies is an importantpoint.Key words: Anti C and Anti A1 with Clinical importance, PNH, AbScreenin