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Medicinski Pregled 2012
Squamous cell carcinoma in mature cystic teratoma of the ovaryDOI: 10.2298/mpns1210429a Keywords: Carcinoma , Squamous Cell , Teratoma , Ovarian Cysts + pathology , Ovarian Neoplasms + pathology , Cell Transformation , Neoplastic , Female , Aged , 80 and over Abstract: Introduction. Malignant transformation is a rare complication of mature cystic teratoma, with squamous cell carcinoma as the most common malignancy (in 75% of cases). In this article we present a case of a well-differentiated squamous cell carcinoma arising in a mature cystic teratoma and discuss the morphological and clinico-pathological features of malignant transformation in teratoma. Case Report. An 80-year-old woman with symptoms of acute abdomen underwent left salpingo-oophorectomy. Gross examination showed a cystic mass measuring 20 cm in diameter, with papillary formation on its internal surface. Histology revealed a well-differentiated squamous cell carcinoma arising in mature cystic teratoma. Squamous epithelium surrounding the tumor was dysplastic. Conclusion. Squamous cell carcinoma in mature cystic teratoma is a rare pathologic event and in most cases it is an accidental pathohistological finding.
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