PRIMARY POSTPARTUM HEMORRHAGE

It is to compare efficacy of Oral Misoprostol with intravenous oxytocin in the management of primary post partumhemorrhage. Design: Quasi experimental study. Place and Duration of Study: Obstetrics and Gynaecology Unit-I, Bahawal VictoriaHospital, Bahawalpur. From 1st December, 2006 to 1st December, 2007. Patients and Method: The study was conducted on 90 patients whowent into post partum hemorrhage during the study period. Cases were divided into two groups each having 45 patients fulfilling the inclusioncriteria. Group ‘A’ had those who received oral misoprostol 600μg and group ‘B’ those who received 5 UNITS intravenous oxytocin. Thevariables analyzed were failure of drug, time taken to control bleeding and side effects of drugs. Students t-test was used for comparisonbetween means and chi-square test for comparison between percentages. Significance was taken at P<0.05. Results: It was noted that failurerate of oral misoprostol was 11.1% and that of oxytocin was 22.2%. Mean time taken to control bleeding by misoprostol was 16.6 minutes and1.311 minutes by intravenous oxytocin. Side effects was observed in 35.5% cases of misoprostol group and 2.22% cases of oxytocin group.Conclusion: The time taken to control bleeding and side effect profile is more better in intravenous oxytocin as compared to oral misoprostol inthe menagemnt of primary postpartum hemorrhage, but number of patients responded to oral misoprostol are more, so it can be used as incombination of oxytocin where oxytocin alone failed to work.