Anti-inflammatory activity of Syzygium cumini leaf against experimentally induced acute and chronic inflammations in rodents

Syzygium cumini (L.) Skeels (Myrtaceae), commonly known as Jam in Bengali, Jamun in Hindi and Black Plum or Black Berry in English, is a large size evergreen tree indigenous to India and is cultivated for its fruits. In the present study, the methanol extract of leaves from S. cumini (MESC) was evaluated for anti-inflammatory activity in experimental acute (carrageenan, histamine and serotonin induced rat paw oedema) and chronic models (cotton pellet induced rat granuloma). In all models, the MESC (100 and 200 mg/kg body wt. p.o.) exhibited significant anti-inflammatory activity (p < 0.001) in a dose dependent manner. These findings revealed that the S. cumini leaf had remarkable acute and chronic anti-inflammatory actions in the tested rodent models.