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Animals  2013 

Variation in Protein and Calorie Consumption Following Protein Malnutrition in Rattus norvegicus

DOI: 10.3390/ani3010033

Keywords: targeted growth, rodent ontogeny, catch-up growth

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Abstract:

Catch-up growth rates, following protein malnutrition, vary with timing and duration of insult, despite unlimited access to calories. Understanding changing patterns of post-insult consumption, relative rehabilitation timing, can provide insight into the mechanisms driving those differences. We hypothesize that higher catch-up growth rates will be correlated with increased protein consumption, while calorie consumption could remain stable. As catch-up growth rates decrease with age/malnutrition duration, we predict a dose effect in protein consumption with rehabilitation timing. We measured total and protein consumption, body mass, and long bone length, following an increase of dietary protein at 40, 60 and 90 days, with two control groups (chronic reduced protein or standard protein) for 150+ days. Immediately following rehabilitation, rats’ food consumption decreased significantly, implying that elevated protein intake is sufficient to fuel catch-up growth rates that eventually result in body weights and long bone lengths greater or equal to final measures of chronically fed standard (CT) animals. The duration of protein restriction affected consumption: rats rehabilitated at younger ages had more drastic alterations in consumption of both calories and protein. While rehabilitated animals did compensate with greater protein consumption, variable responses in different ages and sex highlight the plasticity of growth and how nutrition affects body form.

References

[1]  Jones, D.C.; Bernstein, M.; German, R.Z. Catch-up and targeted growth following variable duration protein restriction: Effects on bone and body mass. J. Morphol. 2011, 272, 485–496, doi:10.1002/jmor.10927.
[2]  Miller, J.P.; German, R.Z. Protein malnutrition affects the growth trajectories of the craniofacial skeleton in rats. J. Nutr. 1999, 129, 2061–2069.
[3]  Reichling, T.D.; German, R.Z. Bones, muscles and visceral organs of protein-malnourished rats (Rattus norvegicus) grow more slowly but for longer durations to reach normal final size. J. Nutr. 2000, 130, 2326–2332.
[4]  Fortman, J.K., 2nd; Reichling, T.; German, R.Z. The impact of maternal protein malnutrition on pre-weaning skeletal and visceral organ growth in neonatal offspring of Rattus norvegicus. Growth Dev. Aging 2005, 69, 39–52.
[5]  Hubert, M.-F.; Laroque, P.; Gillet, J.-P.; Keenan, K.P. The effects of diet, ad libitum feeding, and moderate and severe dietary restriction on body weight, survival, clinical pathology parameters, and cause of death in control Sprague-Dawley rats. Toxicol. Sci. 2000, 58, 195–207, doi:10.1093/toxsci/58.1.195.
[6]  Page, A.J.; Cooper, C.E.; Withers, P.C. Effects of experiment start time and duration on measurement of standard physiological variables. J. Comp. Physiol. B 2011, 181, 657–665, doi:10.1007/s00360-011-0551-9.
[7]  Gautam, B.; Deb, K.; Banerjee, M.; Ali, M.S.; Akhter, S.; Shahidullah, S.M.; Hoque, M.R. Serum zinc and copper level in children with protein energy malnutrition. Mymensingh Med. J. 2008, 17 (2 Suppl), S12–S15.
[8]  Kerstetter, J.E.; O’Brien, K.O.; Insogna, K.L. Dietary protein affects intestinal calcium absorption. Am. J. Clin. Nutr. 1998, 68, 859–865.
[9]  Manach, C.; Scalbert, A.; Morand, C.; Remesy, C.; Jimenez, L. Polyphenols: food sources and bioavailability. Am. J. Clin. Nutr. 2004, 79, 727–747.
[10]  Pencharz, P.B. Protein and energy requirements for ‘optimal’ catch-up growth. Eur. J. Clin. Nutr. 2010, 64 (Suppl 1), S5–S7.
[11]  Morgane, P.J.; Miller, M.; Kemper, T.; Stern, W.; Forbes, W.; Hall, R.; Bronzino, J.; Kissane, J.; Hawrylewicz, E.; Resnick, O. The effects of protein malnutrition on the developing central nervous system in the rat. Neurosci. Biobehav. Rev. 1978, 2, 137–230, doi:10.1016/0149-7634(78)90059-3.
[12]  Riaudel, T.; Guillot, P.; De Decker, L.; Gouraud-Tanguy, A.; Pichierri, S.; Chevalet, P.; Aoudia, V.O.; Maugars, Y.; Berrut, G. Nutrition and osteoporosis in elderly. Geriatr. Psychol. Neuropsychiatr. Vieil. 2011, 9, 399–408.

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