The role of vitamin D in children with recurrent Tonsillopharyngitis

Eighty-four children with recurrent tonsillitis and seventy-one healthy children aging between 2 and 10？years were enrolled in this study. Serum 25-OH vitamin D level was measured with ELISA and vitamin D receptor gene polymorphism (Apa1, Taq 1, Fok1) was determined by PCR. Serum 25-OH vitamin D level below 50？nmol/L was accepted as deficiency. The vitamin D receptor gene polymorphism in each group was compared.The mean age was 5.6 ± 2.4 and 6.1？±？2.7？years in study and control group, respectively. The average serum 25-OH vitamin D level was 142.7？±？68.1？nmol/L in study group and 192.3？±？56.1？nmol/L in control group. There was significant difference between the groups (p < 0.01). In study group, 4.7% (n？=？4) of children had serum 25 OH vitamin D levels below 50？nmol/L. None of the children in control group had serum 25-OH vitamin D level below 50？nmol/L. There was no significant differences in vitamin D receptor gene polymorphisms between groups.Serum 25-OH vitamin D levels in recurrent tonsillitis group were lower than those in healthy children. But, there was no difference in the incidence of vitamin D receptor gene polymorphism between the two groups.