Research studies on polymeric effect of indomethacine transdermal films

The objective of this study was to design and evaluate transdermal patches ofIndomethacine using HPMC, EC and Eudragit RLPO using solvent casting technique.The in vitro drug release studies were performed by using the USP (paddle type)dissolution list apparatus in 1000 ml of 0.1N HCl (Medium Employed) at 37o C roomtemperature for an rpm maintained at 100 within a stipulated time interval of 15 minutes.The withdrawn Samples were analyzed by using UV visible spectrophotometer at 268mm using regent blank. The prepared transdermal patches had undergone physicchemical evaluator parameters such as PMA, PML, swelling index, water vapourtransmission rate, film thickness, weight cheek, and folding Endurance and drug contentclearance. In vitro dissolution study of drug along with different combination ofpolymers; i.e. HPMC, EC and Eudragit has been performed; out of which batch B6 showsthe best moisture of films and the graph representing the best controlled drug release.As the percentage of ethyl cellulose was reduced the rate of the release of the drug wasincreased. [Batch B6 > HPMC: EC: Eudragit RLPO - 2:1:2]. Films with batch code B6shows better stability and suitability. Higuchi’s plot revealed that the predominantMechanism of drug release was diffusion