Effect of polymeric activity on transdermal patches of Glipizide

An effort was made to formulate transdermal patches of Glipizide which is apotent antidiabetic drug by using different ratio of polymers like hydroxy propyl methylcellulose, ethyl cellulose and Eudragit. Eight batches of transdermal patches wereprepared by solvent casting technique in which the best formulation was found out. Thepolymers such as HPMC, Ethyl cellulose, Eudragit were incorporated with Glipizide invarious proportions, out of which the best formulation on the ratio (HPMC: EC: Eudragit- 2:2:1) with the drug was determined. The prepared transdermal patches were uniform inshape and white in color which was calculated for physicochemical characteristics, invitrorelease profile, and in-vivo evaluation on mice. Higuchis plot studies revealed thatthe predominant mechanism of drug release was diffusion.