Inhibition the mutagenicity of vitamin a by using Olea europaea extract

This study aims to investigate the predisposition of the extraction of the extract ofolive leaves (Olea europaea of the family Oleaceae, or the olive family) to frustrate theexcretion of the inherent toxic caused by vitamin A (henceforth VA). After being sure thatthe extraction is inane of any negative effects on the living creature, the following testsare adopted, the mitotic index test of the medulla ossium of the bones, and thechromosomal aberration test. The results showed that toxic dose of vitamin A havecytogenetic effect. It cusses increased in bone marrow cell proliferation and increase inchromosome malformation, the olea leaf extract showed anti-mutagenic activity againstthe cytogenetic effect of vitamin A it decrees chromosome malformation and kept theMitotic index in normal level.