Formulation and evaluation of fast disintegrating tablets of Granisetron HCl using natural polymers

The present research work is to formulate and evaluate fast disintegrating tablets ofGanisetron HCl using natural polymers. Tablets were prepared by direct compressionmethod using different drug polymer concentration. Fourier Transform InfraredSpectroscopy (FT-IR) study revealed no chemical interaction between drug and polymersused. Precompression and postcompression parameters were within the limits for the tablets.Disintegration and dissolution data of tablets were directly proportional to thesuperdisintegrants concentration. Selected fast dissolving tablet F8 containing plantagoovate 5%w/w has released 99.66 % within 3min.