Design and evaluation of timolol maleate ocuserts

A remarkable attempt was made to prepare timolol maleate ocuserts, which issignificant beta adreno receptor antagonist, by the aid of different of different ratio ofcomposition of polymers such as EC, HPMC and Eudragit RS 100. Twelve batches of suitableophthalmic films formulated by the method of solvent casting technique. Out of which thebest formulation was found out the zero order release was observed in batch and wasconsidered as the least drug releasing one. The formulated ocuserts were flexible, uniformand was meant for physic-chemical evaluator parameters, in vitro drug release profile and invivo evaluation made on male rabbit.