Formulation and Evaluation of Naratriptan Orodispersible Tablets Using Superdisintergrants by Direct Compression Method

The present study deals with the formulation and evaluation of Orodispersible tablets (ODT) ofNaratriptan, a typical Antimigraine drug which is highly appropriate as it has ease of administration formentally ill, disabled and uncooperative patients. ODTs have better patient acceptance, compliance,improved biopharmaceutical properties and efficacy compared with conventional oral dosage forms asthey quickly disintegrate/dissolve/disperse in saliva.In the present research work, an attempt was made to design ODTs by addition of super disintegrants.Experimental design was run with four batches containing different concentration of super disintegrants.The optimization results revealed that the effect of super disintegrants result in good disintegrationprofile of 7-8sec (Ideal ODT should disintegrate within 1min), dissolution profile shows that more than90% of the drug releases within 10 minutes, and good dispersion pattern. Crospovidone (5%) andCroscarmellose sodium (4%) are better super disintegrants.The formula F4 possesses good disintegration and dissolution profile with additions of superdisintegrants. The prepared tablets by direct compression using super disintegrants pass all the qualitycontrol tests and FTIR studies reveal that there is no interaction between drug and excipients. Thismethod can also be used to prepare ODTs of antiemetics, antiallergics, and cardiovascular agents etcwhich needs rapid onset of action. Thus, faster disintegration and dissolution of Naratriptan ODT maygive better therapy for the treatments of Migraine.