Adalimumab in patients with ulcerative colitis

Two patients suffering a flare of ulcerative pancolitis are reviewed. Both of them had no response to initial treatment with infliximab. The first one had lost response to it and the second one showed no initial response even after receiving increased doses of infliximab. Subsequently adalimumab subcutaneous infusions were tried. Both of the patients showed considerable clinical and laboratory remission. These two cases describe our department’s experience in the use of adalimumab in ulcerative colitis patients and denote that adalimumab can bring into remission patients with severe ulcerative colitis serving as an alternative option to surgery.