Bioconverted Conjugated Linoleic Acid : A Modulator of Functional Immunity

The present study was conducted to convert linoleic acid into conjugated linoleic acid by microorganism L. acidophilus MTCC 1473 in vitro and then assess the modulation of functions of various immunocytes viz., T and B lymphocytes and macrophage by bioconverted conjugated linoleic acid in vivo in Swiss albino mice employing various immunological parameters like Development of anti-BSA antibody and anti-SRBC antibody by ELISA and Haemagglutination test (HA) test respectively. Functions of macrophages were checked by using Nitroblue tetrazolium chloride reduction test (NBT), inducible nitric oxide synthetase test (iNOS) Phagocytosis Foot-pad swelling method was employed to assess the T-cells mediated immune response. Results revealed that CLA treatment potentiates the functions of all types of immunocytes i.e., T-cells, B-cells and macrophage.