Effect of heat stress on histopathological alterations in kidneys of albino rats

The effect of heat stress was studied over two months (July and August) by using thirty adult male rats. The animals were divided into six groups (five animals per each group) and tested for 7, 14, 21, 28, 35 and 42 days, under controlled condition (45±5°C). The clinical observation indicated significant decrease in activity and body weight associated with oligourea and hypophagia. All these signs were prominent after five days of the experiment. The kidneys of rats under heat stress showed degenerated glomeruli began at 7th day of the study and widening of the capsular space. Atrophy of some glomeruli was also noticed. With prolong exposure to heat changes in the proximal and distal convoluted tubules were prominent when compared with normal rats’ kidneys.