THE DYNAMIC OF CYTOKINE PROFILE IN PATIENTS WITH UPPER RESPIRATORY TRACT INFLAMMATORY DISEASES OF DIFFERENT NOSOLOGY

The level of some cytokines in the serum of patients with inflammatory diseases of URT of different nosology: pharyngitis, tonsillitis, adenoiditis, polyposis was studied. The levels of IL - 8, IL – 10 and IFN – γ were determined. The changes in levels and ratios of cytokines was studied in course of inflammatory process. It was found that in course of inflammatory processes in URT, regardless of nosology form, a reliable increase in levels of IL – 8, IL – 10 is observed. The levels of IFN - γ were higher compared to control values, but differences were insignificant. It was established that a disbalance of IL - 10 / IFN – γ ratio occurs in course of inflammatory processes in URT. The increase in IL-10 level with simultaneous reduction in IFN - γ was more profound in adenoiditis and polyposis patients compared with pharyngitis and tonsillitis groups.