Oxygen reactive species and anti-oxidant response in HIV positive patients and volunteer blood donors, Pereira, Colombia, 2007-2009

Introduction: Oxidative stress is caused by imbalance between the production of Reactive Oxygen Species (ROS) and cellular antioxidant capacity (CAC). Mitochondrial ROS production is constant. Between 2% and 5% of oxygen to the respiratory chain is reduced to generate superoxide anion, O2-, from this there are other molecules and free radicals potentially harmful to the cell. Acquired Immunodeficiency Syndrome (AIDS) is characterized by persistent oxidative stress. The objective of this study was to measure the redox status in HIV + AIDS program of the Municipal Institute of Health Pereira and redox status of people volunteer blood donors medicine program of the Technological University of Pereira years 2007 to 2009 to verify the condition of oxidative stress by spectrophotometric quantification of markers associated with oxidant-antioxidant cell system. Materials and methods: Cross-sectional study with a group of HIV-AIDS and other blood donors, the redox state was measured and correlated with other parameters: age, gender, clinical status, socioeconomic status, diet, nutritional status, immunological stressor consumption, personal history and epidemiologists. Results: Total antioxidant response (TAR), peroxide plasma (PP), oxidative stress index (IEO), carbonyl index (CI), malondialdehyde (MDA) were significantly different in the groups studied. Discussion: In HIV+ there were no significant differences in oxidative stress tests among those who consume and consume no antiretrovirals. Population studies are required to obtain reference values of oxidative stress tests tested here.