Massive Creatine Kinase and Hepatic Enzyme Elevation Due to Quetiapine and Valproic Acid Treatment: A Case Report

In literature, creatine kinase (CK) elevations related to treatment with atypical antipsychotics have been reported in several case studies. In this paper, we present a case of a patient, whose previous and present medical histories showed a massive increase in serum CK and CK myoglobin-band (CK-MB) during quetiapine treatment and in alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT) and lactate dehydrogenase (LDH) levels during valproic acid treatment. The possible mechanisms underlying the CK elevation related with quetiapine and the symptoms that the clinicians should be careful about will be discussed. (Arc-hi-ves of Neu-ropsy-chi-atry 2012; 49: 238-240)