In vitro studies of the influence of glutamatergic agonists on the Na+,K+-ATPase and K+-p-nitrophenylphosphatase activities in the hippocampus and frontal cortex of rats

Our results demonstrated that these glutamatergic agonists did not influence the activities of Na+,K+-ATPase or K+-p-nitrophenylphosphatase in the brain structures analyzed. Assays with lower concentrations of ATP to analyze the preferential activity of the Na+,K+-ATPase isoform with high affinity for ATP did not show any influence either.These findings suggest that under our experimental conditions, the stimulation of glutamatergic receptors does not influence the kinetics of the Na+,K+-ATPase enzyme in the hippocampus and frontal cortex.