Granular cell tumor of the bronchus coexisting with a bronchogenic adenocarcinoma: Case report

Pulmonary granular cell tumors (GCTs) are uncommon and usually benign and their coexistence with bronchogenic adenocarcinoma is rare. We report the case of 50-year-old woman with GCT located in the left lung hilum, which occurred simultaneously with a primary bronchogenic adenocarcinoma in the same area. Contrast CT scan of the head revealed secondary deposits in the right cerebellum, presumably of adenocarcinomas origin. Bronchoscopy revealed narrowing on the beginning of the left lingular bronchus and infiltration of the medial distal wall of the left main bronchus. Large tumor cells with eosinophilic granular cytoplasm were seen on light microscopic examination. Tumor cells fully occupied submucosa and had small, round nuclei with no signs of pleomorphism. Immunohistochemically, these cells were S-100 positive. In small area, groups of atypical oval-shaped cells of adenocarcinomas origin were noticed. This confirmed the diagnosis of GCT coexisting with adenocarcinoma. After consultation with oncologists, the patient was scheduled for further polychemotherapy and radiation treatment.