Effects of exercise and angiotensin-converting enzyme (ACE) on aortic stiffness in the elderly

Senescence is a complex process involving many variables including genetics, lifestyle factors, and chronic diseases, the interaction of which significantly influences the manner in which we age (2). In particular, hypertension and genes of the rennin-angiotensin-aldosterone system have been associated with functional and structural changes of the large arteries, which are thought to contribute to age-related increases in the incidence of cardiovascular disease. Despite mounting evidence implicating sedentary behavior as a significant risk factor in chronic-disease morbidity and mortality among the elderly, there is a limited amount of information on the role of exercise in promoting optimal health and function in older people (27). The purpose of the present review is to discuss the effects of exercise training and angiotensin-converting enzyme (ACE) on aortic stiffness in the elderly.