Effect Of Ether Derivative Cellulose Polymers On Hydration, Erosion And Release Kinetics Of Diclofenac Sodium Matrix Tablets

Objectives: The work aims to investigate the effect ofhydrophilic and hydrophobic polymers swelling and erosionon the release behaviour of DCL-Na from controlled matrixtablets prepared by direct compression and wet-granulationtechniques.Materials and Methods: Powder preformulation studies wereconducted. Tablets were prepared by direct compressiontechnique and their physicochemical properties wereevaluated. Drug-polymer interaction was analyzed by FTIRspectroscopy. The in-vitro drug release study was conductedusing phosphte buffer pH 7.4 as dissolution medium anddifferent kinetic parameters were applied.Results and Discussion: F-1 and F-5 containing ethycelluloseprepared by direct compression and wet granulationtechniques released 94 % and 84 % drug after 24hrs, while F-2and F-6 containing hydroxypropylmethylcellulose polymerprepared by direct compression and wet granulation released98.46 % and 91.25 % drug after within 24 hrs respectively.Ethylcellulose and hydroxypropylmethylcellulose based matrixtablets showed the best anomalous drug release behaviour,with the release exponents “ n ” ranging from 0.685 to 0.809.Conclusion: It has been concluded that ethylcellulose etherderivative polymer is used to prepare oral controlled releasematrix tablet of diclofenac sodium. Fickian drug diffusion,polymer hydration and erosion mechanisms occurredsimultaneously and were considered as the main drug releasecontrolling factors.