Investigation of Interaction Between Flurbiprofen and Fatty Acid Crystals

Objectives: Interaction between flurbiprofen and saturatedfatty acids keeping in view their crystalline nature has beeninvestigated.Materials and Methods: Samples were prepared by coevaporationmethod. FTIR, DSC, XRD, Microscopy (Opticalmicroscopy, Scanning electron microscopy, Atomic forcemicroscopy) techniques were employed for study ofinteraction between drug and fatty acid.Results: FT-IR showed significant changes in the spectralpattern of coevaporates. Possibility of polymorphic changesand eutectic formation was completely ruled out. A betterprobe into interaction was obtained by microscopic techniquesespecially atomic force microscopy.Conclusions: XRD was unable to detect any interactionbetween drug and fatty acid. FT-IR study detected chemicalinteraction between flurbiprofen and fatty acids. Similarobservations were made by DSC study. This study has clearlydemonstrated interaction between flurbiprofen and fatty acidis physicochemical in nature.