Polymorphism of apoptosis regulatory and growth factor genes in patients with chronic lymphocytic leukemia

The objective of the research is to study the role of polymorphic gene variants of Tumor Necrosis Factor-α (TNFA), Bcl-2-associated X protein (BAX), p53 Binding Protein (MDM2), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the development of chronic lymphocytic leukemia (CLL). Methods: The comparative analysis of allele and genotype frequency distribution in CLL patients (N=133) and healthy individuals (N=196) from Bashkortostan Republic has been carried out. Results: Analysis of distribution of genotype and allele frequencies of the genes under study has shown that patients with CLL were likely to demonstrate an increased frequency of GG-genotype and G-allele of polymorphic locus-308G>A of TNFA gene, GG-genotype and G-allele of the polymorphic locus-248G>A of BAX gene, G-allele of the polymorphic locus 309T> G of MDM2 gene and allele C of polymorphic locus 773C>T of bFGF gene.