Formulation and Evaluation of Orodispersible Tablets of a Fluoroquinolone Derivative

Levofloxacin, a fluoroquinolone derivative, is a broad spectrum antibacterial agent used for treating a variety of infections. In this study, orodispersible tablets of levofloxacin were prepared by direct compression method using different superdisintegrants. Taste masking was done for the selected formulation using Eudragit E-100. The tablets were evaluated for hardness, weight variation, friability, disintegration time, water absorption ratio, wetting time and in vitro dissolution. The disintegration time of all the formulations ranged between 20.0 to 76.16 seconds with rapid in vitro dissolution. For conclusion, orodispersible tablets of levofloxacin can be prepared by direct compression method using superdisintegrants with enhanced dissolution and taste masking. Hence, the prepared formulations may improve patient compliance especially in the pediatric and geriatric patients and increase the efficacy of drug for treating infections.