Oral Osmotic System for Delivery of Lornoxicam: Development and In Vitro Charecterization

An oral osmotic system which can deliver Lornoxicam for an extended period of time is developed and characterized in a view to reduce the problems associated with the side effect of Non steroidal anti inflammatory drugs. However, a lot of controlled and sustain release matrix based systems were developed previously still they not overcome the problems like effect of food and other GI factors on release of drug from the delivery system, such drawbacks are overcome by the oral osmotic drug delivery system(tablet). Osmotic drug delivery has become the benchmark to deliver the drugs in controlled-release passion for long term therapy. In diseases like the arthritis patient put on long-term therapy of NSAIDs, which results in a lot of GI side effects and poor drug release. In present study osmotic core tablet was prepared and coated with cellulose acetate; pore was drilled with the help of mechanical microdrill and efforts are taken to improve release of NSAIDs in controlled passion without effect of food and other gastrointestinal factors. Different batches of Lornoxicam was developed and evaluated In –vitro, in which batch 6b release (65.29%) the drug in controlled passion.