The Effect of Hydro-Alcoholic Extract of Morus nigra leaf on Lipids and Sugar in Serum of Diabetic Rats

Morus nigra (mulberries) are all widespread in Pakistan, Iran, India, andAfghanistan, where the tree and the fruit are known by the Persian-derivednames king's or "superior" mulberry. Herbs are rich sources of naturalantioxidants, which are used to cure many diseases in traditional medicine.The researches have shown that some herbal extracts have anti-diabeticeffect, so they can be used to lower blood sugar in people with diabetes. 27male adult rats were randomly selected and divided into three groups asnondiabetic control; diabetic control; diabetic rats treated withhydroalcoholic extract of Morus nigra leaf. In diabetic groups, alloxanmonohydrate (100 mg/kg) was injected intraperitoneally to develop diabetes.Then the Test group received intraperitoneal injection of hydro-alcoholicextract of Morus nigra leaf (100 mg/kg). At last, glucose, cholesterol,triglyceride and HDL contents of the rats' serum sample were determined.The findings show that using hydro-alcoholic extract of Morus nigra leafdecreased glucose, cholesterol and triglyceride contents of diabetic rats'blood serum (p<0.01) and increased HDL content (p>0.05). Considering thesefindings, it is found that Morus nigra leaf can be effective in decreasing bloodsugar and fat in diabetic people.