Development of pulsatile release of Aceclofenac tablets with swelling and rupturable layers of ethyl cellulose

The objective of this study was to develop and evaluate of Aceclofenactablets with swelling and rupturable layers of ethyl cellulose. A tablet systemconsisting Intended for treatment of early morning stiffness and symptomaticrelief from pain in patients with rheumatoid arthritis with a distinctpredetermined lag time of 6 h. Cores containing Aceclofenac as model drugwere prepared by direct compression of different Sodium starch glycolatelevel CT-1 to CT-4) 8 %, 4%, 2% & without disinegrant and were then coatedsequentially with an inner swelling layer containing a superdisintegrant(croscarmellose sodium) and an outer rupturable layer of ethylcellulose.Seven formulations were prepared and formulation F2 possessed good lagtime 6 hr and showed pulsatile drug delivery pattern the tablets In- vitroevaluation tests. Results of this study indicated that by using ethyl celluloseare suitable to optimize pulsatile drug release formulation of Aceclofenac