Prevalence and antibacterial susceptibility pattern of Urinary Tract Infection Causing Human Pathogenic Bacteria

Toxigenic strains of Escherichia coli are common enteric The present studywas conducted to detect common pathogens of urinary tract infection (UTI)and their susceptibility pattern to the commonly used antimicrobial agents inlocal scenario. Urinary tract infection is one of the common clinical conditionsin the patients presenting to the clinics and hospitals. Despite the widespreadavailability of antibiotics, it remains the most common bacterial infection inthe human being. Detection of common pathogens and their antimicrobialsusceptibility pattern is mandatory for effective treatment. In the presentstudy, 40 urine samples were collected from adult patients were analyzed forMultidrug Resistant (MDR) strain isolation and identified. The MDR strainswere identified by the Kirby Bauer method following the definition of theNational Committee of Clinical Laboratory Standards. Out of total 40 samples,32 (80%) samples grew potential pathogens causing UTI. Escherichia coli werethe predominant 10 (31.25%) isolates causing UTI, followed byStaphylococcus aureus -8 (25%), Pseudomonas aeruginosa- 5 (15.62%),Proteus mirabilis -5 (15.62%), Klebsiella pneumoniae -2 (6.25%) and Serratiamarcescens – 2 (6.25%). The mean sensitivity of the antibiotics wasTetracyclin (76.66%), Penicillin (70.83%), Ciprofloxacin (60%). S. aureusshowed 75% resistance to Methicillin, Oxacillin and Vancomycin.Uropathogens are sensitive to Norfloxacin, Co-trimoxazole and Ofloxacin.High prevalence of drug-resistant urinary tract pathogens, particularly toTetracylin, Penicillin and Ampicillin among local patients suggests cautioususe of antibiotic therapy for the treatment. Finally, we suggest that empiricalantibiotic selection should be based on knowledge of the local prevalence ofbacterial organisms and antibiotic sensitivities rather than on universalguidelines.