The inclusion of a partial meal replacement with or without inulin to a calorie restricted diet contributes to reach recommended intakes of micronutrients and decrease plasma triglycerides: A randomized clinical trial in obese Mexican women.

In a randomized controlled clinical trial 144 women (18–50 y) with BMI？≥？25？kg/m2, were allocated into one of the following treatments during 3？months: 1) Two doses/d of a partial meal replacement (PMR), 2) Two doses/d of PMR with inulin (PMR？+？I) , 3) Two doses/d of 5？g of inulin (INU) and 4) Control group (CON). All groups received a low calorie diet (LCD). Weight, height, hip and waist circumference were measured every 2？weeks and body composition, lipids and glucose concentration and nutrient intake were assessed at baseline and after 3？months.All groups significantly reduced weight, BMI, waist and hip circumference. Differences between groups were only observed in BMI and weight adjusted changes: At 45？days PMR group lost more weight than INU and CON groups by 0.9 and 1.2Kg, respectively. At 60？days, PMR？+？I and PMR groups lost more weight than in INU by 0.7 and 1Kg, respectively. Subjects in PMR, PMR？+？I and INU significantly decreased triglycerides. Energy intake was reduced in all groups. Fiber intake increased in PMR？+？I and INU groups. Some minerals and vitamins intakes were higher in PMR and PMR？+？I compared with INU and CON groups.Inclusion of PMR with and without inulin to a LCD had no additional effect on weight reduction than a LCD alone but reduced triglycerides and improved intake of micronutrients during caloric restriction. PMR could be a good alternative for obese populations with micronutrient deficiencies.NCT01505023