Adverse drug reaction reporting in a pharmacovigilance centre of Nepal

BackgroundPharmacovigilance is the “science and activities relating tothe detection, assessment, understanding and prevention ofadverse effects or any other drug related problems”. Nepaljoined the international pharmacovigilance programme as afull member in 2007. KIST Medical College, Lalitpur, Nepaljoined the national programme as a regional centre frommid-July 2008. Currently, the pattern and scope of adversedrug reactions (ADRs) in Nepal remains unexplored.AimsTo observe and analyse the pattern of ADRs at KIST MedicalCollege, Lalitpur, Nepal.MethodA retrospective analysis of all ADRs reported to the centrefrom mid July 2008 to July 2011 was performed. Data wasanalysed for ADR severity, causality, and preventability.ResultsA total of 113 ADR reports were obtained from variousclinical departments. The maximum number of reactionswas due to antimicrobials, followed by anti-hypertensivesand NSAIDs.ConclusionAntimicrobials were the commonest group of drugs causingADRs and the most commonly seen ADR was maculopapularrash followed by diarrhea and vomiting.