New Generation Novel Drugs Designed For Type 2 Diabetes By Insilico Computational Methods which block IRS4

Insulin signaling is mediated by adapter proteins called as IRS family consists of 6 members (Insulin receptor substrates) named from IRS1-IRS6. IRS4, a negative regulator of Insulin signaling. This study was proposed to design cost effective herbal drugs for type 2 diabetes. 3D structure of IRS4 is designed by Homology modeling method of swiss server. Predicted 3D structure is submitted to the Thematics server for interaction site prediction. Target sites of IRS4 are constructed in to 3D structure by molecular builder tool of argus lab software. Chemical structure of ligands were similarly constructed by the same software and both target and ligands were converted into PDB format for docking purposes. Finally the targets and ligands were docked by Hex software. Docking results indicate that the ligands had a potency to bind to the target sites on the substrates. Hence a potential lead compound, for the treatment of type2 diabetes.