PREPARATION AND OPTIMIZATION OF SIMVASTATIN NANOPARTICLE FOR SOLUBILITY ENHANCEMENT AND IN- VIVO STUDY

The aim of the present study was to prepare Simvastatin nanoparticles by nanoprecipitation method using a partially water-miscible solvents and the mutual saturation of the aqueous and organic phases prior to form a nanosuspention in order to reduce the initial thermodynamic instability of the nanoparticles. Because of the self-emulsifying properties of the methacrylic acid co-polymers, it was possible to prepare aqueous dispersions of colloidal size containing up to 30% w/v of Eudragit L100 using methanol as a water-miscible solvent with surfactant. Nanoparticles have become an important area of research in the field of drug delivery, because they have the ability to deliver a wide range of drugs to varying areas of the body for sustained periods of time. The nanoparticles have a higher surface-to-volume ratio as compared with bulk material, and therefore the dose and frequency of administration would be reduced hence increasing patient compliance.