Solid lipid nanoparticles of etoposide using solvent emulsification diffusion technique for parenteral administration

In this investigation, solid lipid nanoparticles were formulated for parenteral administration of etoposide. For this purpose, solvent emulsification diffusion technique in a saline medium was employed. The influence of process variables such as solvent concentration, dilution volume and stabilizer concentration was studied. The optimized formulation was characterized for parameters such as particle size, polydispersity index, zeta potential, drug content, entrapment efficiency and pH measurement. The in vitro erythrocyte toxicity study revealed the parenteral acceptability of the developed formulation. Additionally, acute toxicity study established the safety of the lipid for parenteral administration. Overall, the results suggest the potential use of developed formulation for parenteral delivery of etoposide.