FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF LAMIVUDINE

The aim of present work was to formulate and evaluate fast dissolving tablets of lamivudine to prevent mother to child transmission (MTCT) of HIV virus in perinatal infants. The tablets were prepared by direct compression method, using various superdisintegrants like sodium starch glycolate, croscarmallose sodium, and crospovidone at various concentrations(2%-10%).A total of fifteen formulations were made using one type of superdisintegrants for each of five formulations. Fourier Transmission InfraRed (FT-IR) and DifferentialScanning Calorimetry studies (DSC) were performed to ensure the compatability of drug with the super disintegrants. It was found to be satisfactory. The results of precompression studies reveals that the powder blends of all formulations acquire good flow properties. From the results of post compression studies for tablets of all formulations, it was concluded that the formulation containing 10% crospovidone as superdisintegrants emerged as overall best formulation with lowest disintegration time and highest drug release rate.