FORMULATION AND EVALUATION OF CIPROFLOXACIN TABLET USING A NOVEL BIO-BINDER FROM MACROTYLOMA UNIFLORUM

Macrotyloma uniflorum belongs to the family Fabaceae. It is one of the lesser known beans. It is used as food and fodder. The current aim of our research work is to isolate bio-binder from the seeds of Macrotyloma uniflorum, evaluate for relevant properties and used it as a bio-binder to prepare ciprofloxacin tablets. The bio-material from the seeds was isolated by simplified economic process. The isolated biomaterial was subjected to various physico-chemical tests like solubility, color changing point and pH. The ciprofloxacin hydrochloride granules were prepared using 1 - 5% biomaterial as a bio-binder. The prepared tablets were evaluated for hardness, friability, weight uniformity, disintegration and dissolution profiles. Ciprofloxacin tablets containing starch mucilage as standard binder were produced and assessed comparatively. Our research result reveals that the formulated tablets using bio-material shows significant properties comparative to standard tablets prepared using starch.