Hepatoprotective Activity of Cassia fistula root against Carbon tetrachloride-Induced Hepatic Injury in rats (Wistar)

The protective effects of the alcoholic extract of Cassia fistula root; against CCl4 induced hepatic failure in male albino rats (wistar strain) was investigated. For acute and massive invasion of hepatopathy, CCl4 (s.c) injection of CCl4+Olive Oil in 1:1 ratio; 2ml/kg) was used and the insidious intoxication was evidenced bysignificant turmoil of various biochemical parameters followed by significant (p<0.001) weight loss in toxic control group. The administration of alcoholic root extract (200mg/kg and 100mg/kg of body weight) for 7 days, elicited protective action since the elevated levels of marker enzymes (SGOT, SGPT, ALP) of liver functionswere found to be decreasing progressively in a dose dependent manner. The final body weight was also significantly (p<0.001) increased when compared with the toxic control group. The serum total protein and theserum albumin were also approaching normal values. The results found in alcoholic extract 200mg/kg treated rat were quite promising and were comparable with a standard drug Silymarin. In the alcoholic extract 200mg/kg treated rat group all the marker enzymes were analyzed to be decreasing significantly. The statistically processed results support the conclusion, that the alcoholic root extract of Cassia fistula root (200mg/kg and 100mg/kg) possesses dose dependent, significant protective activity against CCl4 induced hepatotoxicity.