Factors affecting coronary arterial disease, comparative study in male vs female

current research is showing correlation between serum billirubin and coronary arterial disease.CAD is most common in man than in female. Because in this there is also one phenomena work behind itwas level of serum billirubin which is maintain in female by estrogen where as in male there is nomaintenances of S. billirubin this is lower in mail compare to female. Another risk factor also work in malerather than female is like smoking, diabetic or level of blood sugar and also B.M.I.