EFFECT OF CONCENTRATION ON THE RELEASE PROPERTY OF KHAYA SENEGALENSIS GUM IN CHLOROQUINE PHOSPHATE TABLET FORMULATION.

Khaya gum gotten from the bark of khaya senegalensis was used as disintegrant in chloroquine phosphate tablets and was evaluated and compared to maize starch and microcrystalline cellulose. Batches of 5, 7.5 and 10%w/w were formulated for the three excipients.Khaya gum was observed to swell to about ten (10) times its weight in water. The granules of all the batches were observed to have good flow properties. Tablets of all the batches containing khaya gum were observed to be softer, disintegrated faster and had greater dissolution than the tablets of the MCC batches. An increase in the concentration of the khaya gum led to slower disintegration of the tablets. The dissolution profile showed that an increase in the concentration of khaya gum led to a retardation in the release of the drug and the effective concentration for fast disintegration and quick drug release was found to be 5%w/w. The mechanism of disintegration and drug release was attributed to the gum’s water uptake and swelling capacity.