Kandungan Kimia dan Uji Antiinflamasi Ekstrak Etanol Lantana camara L. pada Tikus Putih (Rattus norvegicus L.) Jantan

Lantana camara L. is a widely distributed plant on tropics region belonging to the Family Verbenaceae. In Indonesia, the plant is used in traditional medicines of edema and rheumatisms. The aims of this research were to compare saponins, flavonoids, and essential oils constituents among the roots, the leaves, and the fruits and to know about anti-inflammatory effects of ethanolic extracts of L. camara on white male rats. The framework of the research was that the saponins, flavonoids, and essential oils constituents of L. camara have an anti-inflammatory effect. Organs with the highest constituents of saponins, flavonoids and essential oils would expect giving optimal anti-inflammatory effects. Complete Randomized Design with five treatment groups, each of the treatment had five repetitions, was used in this study. Each group have been treated: Group I CMC 0.5% control (placebo), Group II positive control (Na-diclofenac), Group III, IV and V giving ethanolic extracts of L. camara dose 720, 1080 and 1440 mg/kg BW, respectively. The inflammation was produced by sub plantar injection of carrageenan suspension in the right hind paw of the rats. The quantitative data of Area under Curve of edema percentage were analyzed statistically with SPSS program using One-Way ANOVA followed by LSD test. The results showed that the highest constituents of saponins, flavonoids, and essential oils were found in the leaves. Ethanolic extracts of L. camara’s leaves dose 720 mg/kg BW had given the highest anti- inflammatory effects (38.1%).