Anti-inflammatory activity of Cordia dichotoma forst f. seeds extracts

The effects of Cordia dichotoma forst f. seeds extracts on different phases of acute inflammationwere examined. Investigations were performed using different phlogistic agents-induced paw edema viz.,Carrageenan-induced paw oedema and Dextran- induced paw oedema in rats. Various extracts (ethanoland aqueous) of Cordia dichotoma forst seeds at a dose of 250 mg/kg and 500 mg/kg orally were tested.Diclofenac sodium at the dose of 10mg/kg was used as standard. Both the extracts showed significantactivity (*p<0.05 & **p<0.01) compared with the control in both of these models. The dry powdered seedswere found to contain alkaloids, glycosides, saponins, tannins and carbohydrates. Thus it is revealed fromthe screening model used that the ethanol extract and aqueous fraction of this plant possesses acute antiinflammatoryactivity.