Antihyperlipidemic Effect of Flax Lignan Concentrate in Triton Induced Hyperlipidemic Rats

Linum usitatissimum commonly known as flax (also known as linseed) is a member of the genus Linum in the family Linaceae. The objective of study was to investigate the antihyperlipidemic effect of Flax Lignan Concentrate (FLC) in triton WR-1339 induced hyperlipidaemic rats. Hyperlipidemia was induced by intraperitoneal injection of triton WR-1339 (200 mg kg-1). Triton WR-1339 (200 mg kg-1, i.p.) injection significantly (p<0.001) increased total cholesterol, triglyceride, very high density lipoprotein at 24 h and thereafter at 48 h reduction was observed. FLC showed dose dependant decrease in the total cholesterol, triglyceride and very high density lipoprotein. FLC increased HDL-cholesterol whereas HDL decreased in the rats treated with triton alone. Atorvastatin was more effective than FLC in all the respect. Administration of triton alone increased both coronary risk index and low density lipoprotein and FLC and atorvastatin treatment decreased both the indices. It is concluded that FLC reduces total cholesterol, triglyceride, very high density lipoprotein, low density lipoprotein, coronary risk index and increased HDL in triton induced hyperlipidaemia in rats.