Investigation of the Central and Peripheral Analgesic and Anti-inflammatory Activity of Kutajarishta, an Indian Ayurvedic formulation

Kutajarishta (KTJ) is an Ayurvedic formulation approved by the “National formulary of Ayurvedic Medicine 2011”, of Bangladesh. It is widely available in the Bangladeshi market as an effective preparation to treat lumbago, sciatia and arthritic pain of joints. Our present studies make an attempt toward identifying probable anti-nociceptive and anti-inflammatory mechanisms of KTJ. KTJ, at three doses, (10mL/kg, 20mL/kg, and 40mL/kg) showed no involvement of the CNS in anti-nociceptive activity of KTJ. Carrageenan induced paw edema and acetic acid writhing tests both gave significant results (P ≤ 0.05), indicating possible peripheral analgesic and anti-inflammatory action. Formalin induced paw-licking test showed that KTJ had significant effect in suppressing inflammatory pain (P≤0.05) but not neurogenic pain. Hence our study shows anti-inflammatory and peripheral analgesic action for KTJ.