SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SUBSTITUTED TETRAHYDROTHIENO [2,3-C]PYRIDIN-2-YL) SCHIFF BASE DERIVATIVES

As a part of systematic investigation of synthesis, characterization and biological activity of several new substituted Tetrahydrothieno [2,3-c]pyridin-2-yl) Schiff base derivatives, (1a-1k) have been synthesized by well known chemical reaction of one active methylene containing moiety with a carbonyl function and Sulfur powder to give 2- Amino thiophene ring system followed by derivatization of amino into schiffbase using different aromatic aldehydes. The structures of all the synthesized compounds have been determined by their spectral and micro analytical data. All the compounds have been evaluated for their antibacterial activity against Gram Positive bacteria like Staphylococcus aureus, Bacillus subtilis and Gram Negative bacteria like Escherichia coli, Salmonella peratyphi B and they were also evaluated for antifungal activity against Candida albicans and Aspergillus niger at different concentrations. Most of the synthesized compounds exhibited significant anti-bacterial and anti-fungal activities.