IN VITRO EFFECTS OF CEFTRIAXONE ON GROWTH OF HUMAN RHABDOMYOSARCOMA (RD) AND ON RAT EMBRYO FIBROBLASTS (REF) CELL LINES

Many reports demonstrated that antibiotics like cefazoline, ciprofloxacin, trimethoprime-sulfamethoxazole and others have the ability to inhibit growth of various cell lines. Thus, this study was designed to investigate whether or not ceftriaxone may possess cell growth inhibition using In vitro study and utilizing two cell lines (human rhabdomyosarcoma (RD) and rat embryo fibroblasts (REF). Various concentrations of Ceftriaxone (62.5, 125, 250, 500 and 1000 mcg/ml) were utilized in this study. The drug relatively caused concentration-dependent inhibition on growth of the intended cell lines used in this study, where, the growth inhibition induced by the drug was statistically significant at 125mcg/ml and above. The results obtained from this work encourage further study of the possibility of clinical application of ceftriaxone to prevent the occurrence of different tumors.