Microwave Assisted Synthesis of Fluoro, Chloro 2-Substituted Benzimidazole Thiazine Derivatives for Antibacterial and Analgesic Activities

The flouro, chloro 2-acetyl benzimidazole were prepared by the microwave induced reactionbetween 3-chloro-4-fluorobenzene-1, 2- diamine and lactic acid, followed by oxidation withpotassium permanganate and aluminum oxide. The chalcone derivative of fluoro,chloro-2-acetyl benzimidazole were prepared by the condensation with different aldehydes and theresulting compounds were cyclized with thiourea, to get the thiazine derivatives of fluoro,chloro benzimidazole. The synthesized compounds have been characterized and confirmedby TLC, elemental analysis, IR, and 1H NMR spectroscopy and screened for theirantibacterial and analgesic activity. Compounds containing electron withdrawing groups inthe substituted Benzimidazole thiazine were found to show potent analgesic and antibacterialactivities.