Protective Effect of Docosahexaenoic Acid on Aluminium Induced Autonomic and Gross Behavioural Changes in Male Albino Rats

Essential omega-3 polyunsaturated fatty acids are crucial for development and function of the brain. Itmay help to ameliorates neurotoxicity. Aluminium (Al) is a potent neurotoxic element, which plays animportant role in the degeneration of nerve cells of experimental animals as well as human brain. It isassociated with Alzheimer’s like symptoms leading to cognitive decline. In the present study, weevaluated autonomic response, gross behavioural and sensory response in rats following 100 mg / kgb.w. of AlCl3 treated rats for 90 days. 50mg, 100mg and 200mg of Docosahexaenoic acid (DHA) weretreated along with AlCl3 with for 90 days. Different behavioural responses like autonomic responses,gross behavioural and sensory were evaluated in rats. Catalepsy, posture righting reflex, nocieceptiveresponse of rats were changed and significant altered gross behavioural and autonomic response werefound in Al treated rats. 100mg of DHA shows maximum reversal in Al induced behavioural changes.On the basis of results it may conclude that DHA ameliorate Al behavioural changes in rats. 100mgDHA dose were considered significant in the study. Further study may require in different animalmodel for depth knowledge.