Nephroprotective Effect of Fresh Leaves Extracts of Sida Cordifolia Linn in Gentamicin Induced Nephrotoxicity in Rats Bhatia Lovkesh*, Bhatia Vivek, Grover Manav

The present study was aimed at evaluating the ethanolic and aqueous extracts of leaves of Sida cordifolia Linn. for nephroprotective effect in gentamicin-induced nephrotoxicity in rats. Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of gentamicin 100 mg/kg/d for eight days. Effect of concurrent administration of ethanolic and aqueous extracts of leaves of Sida cordifolia Linn.at dose of 200 and 400 mg/kg b.w. respectively was given by oral route. Serum creatinine, serum urea, urine creatinine and blood urea nitrogen (BUN) were determined on day 9. Histopathological study of kidney was also done. Both the extracts produced significant(P<0.001)nephroprotective activity in Gentamicin induced nephrotoxicity models as evident by decrease in serum creatinine, serum urea, urine creatinine and BUN levels in extract treated groups which was elevated by gentamicin, which was further confirmed by histopathological study. Gentamicin induced glomerular congestion, blood vessel congestion, and epithelial desquamation, accumulation of inflammatory cells and necrosis of the kidney cells were found to be reduced in the groups receiving extracts of Sida cordifolia Linn.along with gentamicin.